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COVID-19 in adult a...
COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)
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Marchesi, F (author)
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Salmanton-Garcia, J (author)
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Emarah, Z (author)
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show more...
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Piukovics, K (author)
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Nucci, M (author)
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Lopez-Garcia, A (author)
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Racil, Z (author)
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Farina, F (author)
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Popova, M (author)
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Zompi, S (author)
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Audisio, E (author)
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Ledoux, MP (author)
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Verga, L (author)
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Weinbergerova, B (author)
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Szotkovski, T (author)
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Da Silva, MG (author)
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Fracchiolla, N (author)
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De Jonge, N (author)
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Collins, G (author)
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Marchetti, M (author)
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Magliano, G (author)
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Garcia-Vidal, C (author)
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Biernat, MM (author)
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Van Doesum, J (author)
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Machado, M (author)
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Demirkan, F (author)
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Al-Khabori, M (author)
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Zak, P (author)
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Visek, B (author)
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Stoma, I (author)
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Mendez, GA (author)
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Maertens, J (author)
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Khanna, N (author)
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Espigado, I (author)
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Dragonetti, G (author)
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Fianchi, L (author)
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Del Principe, MI (author)
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Cabirta, A (author)
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Ormazabal-Velez, I (author)
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Jaksic, O (author)
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Buquicchio, C (author)
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Bonuomo, V (author)
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Batinic, J (author)
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Omrani, AS (author)
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Lamure, S (author)
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Finizio, O (author)
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Fernandez, N (author)
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Falces-Romero, I (author)
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- Blennow, O (author)
- Karolinska Institutet
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Bergantim, R (author)
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Ali, N (author)
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Win, S (author)
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Van Praet, J (author)
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Tisi, MC (author)
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Shirinova, A (author)
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Schonlein, M (author)
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Prattes, J (author)
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Piedimonte, M (author)
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Petzer, V (author)
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Navratil, M (author)
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Kulasekararaj, A (author)
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Jindra, P (author)
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Sramek, J (author)
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Glenthoj, A (author)
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Fazzi, R (author)
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De Ramon-Sanchez, C (author)
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Cattaneo, C (author)
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Calbacho, M (author)
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Bahr, NC (author)
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El-Ashwah, S (author)
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Cordoba, R (author)
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Hanakova, M (author)
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Zambrotta, GPM (author)
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Zambrotta, G (author)
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Sciume, M (author)
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Booth, S (author)
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Rodrigues, RN (author)
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Sacchi, MV (author)
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Garcia-Pouton, N (author)
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Martin-Gonzalez, JA (author)
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Khostelidi, S (author)
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Grafe, S (author)
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Rahimli, L (author)
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Ammatuna, E (author)
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Busca, A (author)
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Corradini, P (author)
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Hoenigl, M (author)
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Klimko, N (author)
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Koehler, P (author)
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Pagliuca, A (author)
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Passamonti, F (author)
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Cornely, OA (author)
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Pagano, L (author)
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(creator_code:org_t)
- 2022-05-12
- 2023
- English.
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 108:1, s. 22-33
- Related links:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Marchesi, F
-
Salmanton-Garcia ...
-
Emarah, Z
-
Piukovics, K
-
Nucci, M
-
Lopez-Garcia, A
-
show more...
-
Racil, Z
-
Farina, F
-
Popova, M
-
Zompi, S
-
Audisio, E
-
Ledoux, MP
-
Verga, L
-
Weinbergerova, B
-
Szotkovski, T
-
Da Silva, MG
-
Fracchiolla, N
-
De Jonge, N
-
Collins, G
-
Marchetti, M
-
Magliano, G
-
Garcia-Vidal, C
-
Biernat, MM
-
Van Doesum, J
-
Machado, M
-
Demirkan, F
-
Al-Khabori, M
-
Zak, P
-
Visek, B
-
Stoma, I
-
Mendez, GA
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Maertens, J
-
Khanna, N
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Espigado, I
-
Dragonetti, G
-
Fianchi, L
-
Del Principe, MI
-
Cabirta, A
-
Ormazabal-Velez, ...
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Jaksic, O
-
Buquicchio, C
-
Bonuomo, V
-
Batinic, J
-
Omrani, AS
-
Lamure, S
-
Finizio, O
-
Fernandez, N
-
Falces-Romero, I
-
Blennow, O
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Bergantim, R
-
Ali, N
-
Win, S
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Van Praet, J
-
Tisi, MC
-
Shirinova, A
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Schonlein, M
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Prattes, J
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Piedimonte, M
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Petzer, V
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Navratil, M
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Kulasekararaj, A
-
Jindra, P
-
Sramek, J
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Glenthoj, A
-
Fazzi, R
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De Ramon-Sanchez ...
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Cattaneo, C
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Calbacho, M
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Bahr, NC
-
El-Ashwah, S
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Cordoba, R
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Hanakova, M
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Zambrotta, GPM
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Zambrotta, G
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Sciume, M
-
Booth, S
-
Rodrigues, RN
-
Sacchi, MV
-
Garcia-Pouton, N
-
Martin-Gonzalez, ...
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Khostelidi, S
-
Grafe, S
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Rahimli, L
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Ammatuna, E
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Busca, A
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Corradini, P
-
Hoenigl, M
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Klimko, N
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Koehler, P
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Pagliuca, A
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Passamonti, F
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Cornely, OA
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Pagano, L
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show less...
- Articles in the publication
-
Haematologica
- By the university
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Karolinska Institutet