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Animal models of Alport syndrome: advancing the prospects for effective human gene therapy
- Heikkila, P (author)
-
- Tryggvason, K (author)
- Karolinska Institutet
- Thorner, P (author)
- (creator_code:org_t)
- 2000-01-14
- 2000
- English.
- In: Experimental nephrology. - : S. Karger AG. - 1018-7782 .- 1660-2129. ; 8:1, s. 1-7
- Journal article (peer-reviewed)
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- Several animal models for Alport syndrome have been described. These are available for studies on the pathogenetic mechanisms of the disease, as well as for the development of new technologies for gene therapy in this progressive hereditary kidney disease. This review summarizes current knowledge on the molecular basis of Alport syndrome, and on the animal models which all remarkably well resemble the human disease. Recent work aimed at the development of gene therapy, including hurdles and progress are discussed.
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