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  • Heikkila, P (author)

Animal models of Alport syndrome: advancing the prospects for effective human gene therapy

  • Article/chapterEnglish2000

Publisher, publication year, extent ...

  • 2000-01-14
  • S. Karger AG,2000

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  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:16284768
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:16284768URI
  • https://doi.org/10.1159/000020641DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Several animal models for Alport syndrome have been described. These are available for studies on the pathogenetic mechanisms of the disease, as well as for the development of new technologies for gene therapy in this progressive hereditary kidney disease. This review summarizes current knowledge on the molecular basis of Alport syndrome, and on the animal models which all remarkably well resemble the human disease. Recent work aimed at the development of gene therapy, including hurdles and progress are discussed.

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  • Tryggvason, KKarolinska Institutet (author)
  • Thorner, P (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Experimental nephrology: S. Karger AG8:1, s. 1-71018-77821660-2129

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