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Free insulin-like growth factor I: are we hunting a ghost?
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- Bang, P (author)
- Karolinska Institutet
- Ahlsen, M (author)
- Berg, U (author)
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- (creator_code:org_t)
- 2004-11-17
- 2001
- English.
- In: Hormone research. - : S. Karger AG. - 0301-0163. ; 5555 Suppl 2, s. 84-93
- Journal article (peer-reviewed)
Abstract
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- During the last decade, there has been an increasing number of publications reporting concentrations of free dissociable insulin-like growth factor I (IGF-I) in serum or plasma. The goal for attempting to measure free IGF-I in a serum sample in vitro has been to obtain information about the bioactivity of IGF-I in target tissues, and thus relate a measurable parameter to biological responses such as longitudinal growth or glucose disappearance rate. In this review, the serum free IGF-I approach is placed into a physiological perspective. In addition, methodological aspects are discussed and suggestions for the validation of free IGF-I assays are presented.
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