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Mercury uptake and kinetics after ingestion of dental amalgam
- af Geijersstam, E (author)
-
- Sandborgh-Englund, G (author)
- Karolinska Institutet
- Jonsson, F (author)
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- Ekstrand, J (author)
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- (creator_code:org_t)
- 2016-11-08
- 2001
- English.
- In: Journal of dental research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 80:9, s. 1793-1796
- Journal article (peer-reviewed)
Abstract
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- The aim of the present study was to investigate the G-I uptake of mercury (Hg) after intake of a single dose of amalgam-Hg, followed by pharmacokinetic analysis of the data. Eleven volunteers without amalgam fillings ingested 1.00 g amalgam powder. Hg in plasma vs. time was analyzed with a two-compartment model by means of mixed-effects modeling. A fraction of the absorption rate of Hg to the central compartment was inversely proportional to the plasma ferritin levels. The population mean half-life of the terminal phase of Hg in plasma was 37 days, with a considerable standard deviation in the population. The absorbed fraction of the administered dose was estimated to be about 0.04%. It is concluded that the G-I uptake of Hg is of quantitative importance during dental treatment.
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