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Abnormal reaction t...
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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1999-05-03
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Rockefeller University Press,1999
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1928610
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1928610URI
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https://doi.org/10.1083/jcb.145.3.503DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin. We have shown that astrocytes in mice deficient for both GFAP and vimentin (GFAP−/−vim−/−) cannot form IFs even when nestin is expressed and are thus devoid of IFs in their reactive state. Here, we have studied the reaction to injury in the central nervous system in GFAP−/−, vimentin−/−, or GFAP−/−vim−/− mice. Glial scar formation appeared normal after spinal cord or brain lesions in GFAP−/− or vimentin−/− mice, but was impaired in GFAP−/−vim−/− mice that developed less dense scars frequently accompanied by bleeding. These results show that GFAP and vimentin are required for proper glial scar formation in the injured central nervous system and that some degree of functional overlap exists between these IF proteins.
Added entries (persons, corporate bodies, meetings, titles ...)
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Johansson, CB
(author)
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Eliasson, C
(author)
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Stakeberg, J
(author)
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Wallen, A
(author)
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Perlmann, TKarolinska Institutet
(author)
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Lendahl, UKarolinska Institutet
(author)
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Betsholtz, C
(author)
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Berthold, CH
(author)
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Frisen, JKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:The Journal of cell biology: Rockefeller University Press145:3, s. 503-5140021-95251540-8140
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Pekny, M
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Johansson, CB
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Eliasson, C
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Stakeberg, J
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Wallen, A
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Perlmann, T
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Lendahl, U
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Betsholtz, C
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Berthold, CH
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Frisen, J
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Karolinska Institutet