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A DLST genotype associated with reduced risk for Alzheimer's disease
- Sheu, KFR (author)
- Brown, AM (author)
- Kristal, BS (author)
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- Kalaria, RN (author)
- Lannfelt, L (author)
- Blass, JP (author)
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- (creator_code:org_t)
- 1999-04-01
- 1999
- English.
- In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 52:7, s. 1505-1507
- Journal article (peer-reviewed)
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- Article abstract Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial α-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
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- Sheu, KFR
- Brown, AM
- Kristal, BS
- Kalaria, RN
- Lilius, L
- Lannfelt, L
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- Blass, JP
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- Neurology
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- Karolinska Institutet
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