Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1929053" >
A DLST genotype ass...
A DLST genotype associated with reduced risk for Alzheimer's disease
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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1999-04-01
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Ovid Technologies (Wolters Kluwer Health),1999
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1929053
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1929053URI
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https://doi.org/10.1212/wnl.52.7.1505DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Article abstract Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial α-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
Added entries (persons, corporate bodies, meetings, titles ...)
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Brown, AM
(author)
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Kristal, BS
(author)
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Kalaria, RN
(author)
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Lilius, LKarolinska Institutet
(author)
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Lannfelt, L
(author)
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Blass, JP
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Neurology: Ovid Technologies (Wolters Kluwer Health)52:7, s. 1505-15070028-38781526-632X
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