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Albumin synthesis i...
Albumin synthesis in humans increases immediately following the administration of endotoxin
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- Barle, H (author)
- Karolinska Institutet
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- Januszkiewicz, A (author)
- Karolinska Institutet
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- Hallstrom, L (author)
- Karolinska Institutet
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Essen, P (author)
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McNurlan, MA (author)
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Garlick, PJ (author)
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- Wernerman, J (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2002-10-23
- 2002
- English.
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In: Clinical science (London, England : 1979). - : Portland Press Ltd.. - 0143-5221 .- 1470-8736. ; 103:5, s. 525-531
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https://doi.org/10.1...
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Abstract
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- In order to investigate the immediate (i.e. within 3h) response of albumin synthesis to the administration of endotoxin, as a model of a moderate and well controlled catabolic insult, two measurements employing L-[2H5]phenylalanine were performed in 16 volunteers. One group (n = 8) received an intravenous injection of endotoxin (4ng/kg; lot EC-6) immediately after the first measurement of albumin synthesis, whereas the other group received saline. A second measurement was initiated 1h later. In the endotoxin group, the fractional synthesis rate of albumin was 6.9±0.6%/day (mean±S.D.) in the first measurement. In the second measurement, a significant increase was observed (9.6±1.2%/day; P<0.001). The corresponding values in the control group were were 6.6±0.6%/day and 7.0±0.6%/day respectively (not significant compared with first measurement and P<0.001 compared with the second measurement in the endotoxin group). The absolute synthesis rates of albumin were 148±35 and 201±49mg·kg-1·day-1 before and after endotoxin (P<0.01). In the control group, the corresponding values were 131±21 and 132±20mg·kg-1·day-1 (not significant compared with the first measurement and P<0.01 compared with the second measurement in the endotoxin group). In conclusion, these results indicate that albumin synthesis increases in the very early phase after a catabolic insult, as represented by the administration of endotoxin.
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