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Abnormal vascular f...
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
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Zhu, Y (author)
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Bian, Z (author)
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Lu, P (author)
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Karas, RH (author)
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Bao, L (author)
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Cox, D (author)
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Hodgin, J (author)
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Shaul, PW (author)
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Thoren, P (author)
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Smithies, O (author)
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- Gustafsson, JA (author)
- Karolinska Institutet
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Mendelsohn, ME (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2002
- 2002
- English.
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 295:5554, s. 505-508
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https://doi.org/10.1...
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Abstract
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- Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood vessels from estrogen receptor β (ERβ)–deficient mice exhibit multiple functional abnormalities. In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ-mediated increase in inducible nitric oxide synthase expression. In contrast, estrogen augments vasoconstriction in blood vessels from ERβ-deficient mice. Vascular smooth muscle cells isolated from ERβ-deficient mice show multiple abnormalities of ion channel function. Furthermore, ERβ-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERβ in the regulation of vascular function and blood pressure.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhu, Y
-
Bian, Z
-
Lu, P
-
Karas, RH
-
Bao, L
-
Cox, D
-
show more...
-
Hodgin, J
-
Shaul, PW
-
Thoren, P
-
Smithies, O
-
Gustafsson, JA
-
Mendelsohn, ME
-
show less...
- Articles in the publication
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Science (New Yor ...
- By the university
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Karolinska Institutet