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Neuropeptide y in euthymic lithium-treated women with bipolar disorder
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- El Khoury, A (author)
- Karolinska Institutet
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- Mathe, AA (author)
- Karolinska Institutet
- (creator_code:org_t)
- 2004-09-14
- 2004
- English.
- In: Neuropsychobiology. - : S. Karger AG. - 0302-282X .- 1423-0224. ; 50:3, s. 239-243
- Journal article (peer-reviewed)
Abstract
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- Plasma neuropeptide Y-like immunoreactivity (NPY-LI) and platelet cyclic AMP (cAMP) activity were determined in 13 women with bipolar disorder stabilized on lithium (Li) and 12 matched healthy controls. No differences in plasma NPY-LI were found between the two groups. In euthymic Li-treated bipolar patients, there was an inverse correlation between plasma NPY-LI levels and intracellular cAMP in prostaglandin E<sub>1</sub>-stimulated platelets. A positive correlation was found between plasma NPY-LI levels and age in both the patient and the control group. Our findings support earlier findings that NPY is capable of inhibiting adenylyl cyclase and that aging is a physiological factor in regulating NPY-LI levels.
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