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Apoptosis and necro...
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
- Article/chapterEnglish1995
Publisher, publication year, extent ...
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1995-08
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Proceedings of the National Academy of Sciences,1995
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1936872
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1936872URI
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https://doi.org/10.1073/pnas.92.16.7162DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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N-Methyl-D-aspartate (NMDA) receptor-mediated neurotoxicity may depend, in part, on the generation of nitric oxide (NO.) and superoxide anion (O2.-), which react to form peroxynitrite (OONO-). This form of neurotoxicity is thought to contribute to a final common pathway of injury in a wide variety of acute and chronic neurologic disorders, including focal ischemia, trauma, epilepsy, Huntington disease, Alzheimer disease, amyotrophic lateral scelerosis, AIDS dementia, and other neurodegenerative diseases. Here, we report that exposure of cortical neurons to relatively short durations or low concentrations of NMDA, S-nitrosocysteine, or 3-morpholinosydnonimine, which generate low levels of peroxynitrite, induces a delayed form of neurotoxicity predominated by apoptotic features. Pretreatment with superoxide dismutase and catalase to scavenge O2.- partially prevents the apoptotic process triggered by S-nitrosocysteine or 3-morpholinosydnonimine. In contrast, intense exposure to high concentrations of NMDA or peroxynitrite induces necrotic cell damage characterized by acute swelling and lysis, which cannot be ameliorated by superoxide dismutase and catalase. Thus, depending on the intensity of the initial insult, NMDA or nitric oxide/superoxide can result in either apoptotic or necrotic neuronal cell damage.
Added entries (persons, corporate bodies, meetings, titles ...)
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KRAINC, D
(author)
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ANKARCRONA, MKarolinska Institutet
(author)
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NICOTERA, P
(author)
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LIPTON, SA
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences92:16, s. 7162-71660027-8424
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In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences92:16, s. 7162-71661091-6490
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