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Expression of 5-lip...
Expression of 5-lipoxygenase in differentiating human skin keratinocytes
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JANSSENTIMMEN, U (author)
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VICKERS, PJ (author)
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WITTIG, U (author)
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LEHMANN, WD (author)
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STARK, HJ (author)
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FUSENIG, NE (author)
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ROSENBACH, T (author)
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- RADMARK, O (author)
- Karolinska Institutet
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- SAMUELSSON, B (author)
- Karolinska Institutet
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HABENICHT, AJR (author)
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(creator_code:org_t)
- 1995-07-18
- 1995
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:15, s. 6966-6970
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https://doi.org/10.1...
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Abstract
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- We studied the expression of arachidonate 5-lipoxygenase (5-LO) in a cell line of human keratinocytes (HaCaT) and in normal human skin keratinocytes in tissue culture. In undifferentiated keratinocytes 5-LO gene expression was low or undetectable as determined by 5-LO mRNA, protein, cell-free enzyme activity, and leukotriene production in intact cells. However, after shift to culture conditions that promote conversion of prokeratinocytes into a more differentiated phenotype, 5-LO gene expression was markedly induced in HaCaT cells and, to a lesser extent, in normal keratinocytes. These results show that 5-LO gene expression is an intrinsic property of human skin keratinocytes.
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- art (subject category)
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JANSSENTIMMEN, U
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VICKERS, PJ
-
WITTIG, U
-
LEHMANN, WD
-
STARK, HJ
-
FUSENIG, NE
-
show more...
-
ROSENBACH, T
-
RADMARK, O
-
SAMUELSSON, B
-
HABENICHT, AJR
-
show less...
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Proceedings of t ...
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Proceedings of t ...
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Karolinska Institutet