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Isomer-specific ant...
Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression
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Ryder, JW (author)
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Portocarrero, CP (author)
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Song, XM (author)
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Cui, L (author)
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Yu, M (author)
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Combatsiaris, T (author)
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- Galuska, D (author)
- Karolinska Institutet
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Bauman, DE (author)
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Barbano, DM (author)
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Charron, MJ (author)
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- Zierath, JR (author)
- Karolinska Institutet
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Houseknecht, KL (author)
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(creator_code:org_t)
- American Diabetes Association, 2001
- 2001
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 50:5, s. 1149-1157
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http://diabetes.diab...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
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- Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator–activated receptor (PPAR)-γ response elements in vitro. Here, our aim was to elucidate the effect(s) of specific CLA isomers on whole-body glucose tolerance, insulin action in skeletal muscle, and expression of genes important in glucose and lipid metabolism. ZDF rats were fed either a control diet (CON), one of two CLA supplemented diets (1.5% CLA) containing differing isoforms of CLA (47% c9,t11; 47.9% c10,t12, 50:50; or 91% c9,t11, c9,t11 isomers), or were pair-fed CON diet to match the intake of 50:50. The 50:50 diet reduced adiposity and improved glucose tolerance compared with all other ZDF treatments. Insulin-stimulated glucose transport and glycogen synthase activity in skeletal muscle were improved with 50:50 compared with all other treatments. Neither phosphatidlyinositol 3-kinase activity nor Akt activity in muscle was affected by treatment. Uncoupling protein 2 in muscle and adipose tissue was upregulated by c9,t11 and 50:50 compared with ZDF controls. PPAR-γ mRNA was downregulated in liver of c9,t11 and pair-fed ZDF rats. Thus, the improved glucose tolerance in 50:50 rats is attributable to, at least in part, improved insulin action in muscle, and CLA effects cannot be explained simply by reduced food intake.
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- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Ryder, JW
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Portocarrero, CP
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Song, XM
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Cui, L
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Yu, M
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Combatsiaris, T
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show more...
-
Galuska, D
-
Bauman, DE
-
Barbano, DM
-
Charron, MJ
-
Zierath, JR
-
Houseknecht, KL
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show less...
- Articles in the publication
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Diabetes
- By the university
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Karolinska Institutet