Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1939151" >
Deficiency of phosp...
Deficiency of phosphofructo-1-kinase/muscle subtype in humans is associated with impairment of insulin secretory oscillations
-
Ristow, M (author)
-
Carlqvist, H (author)
-
Hebinck, J (author)
-
show more...
-
Vorgerd, M (author)
-
Krone, W (author)
-
Pfeiffer, A (author)
-
Muller-Wieland, D (author)
-
- Ostenson, CG (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- American Diabetes Association, 1999
- 1999
- English.
-
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 48:8, s. 1557-1561
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- In healthy humans, insulin is secreted in an oscillatory manner. While the underlying mechanisms generating these oscillations are not fully established, increasing evidence suggests a central role for phosphofructo-1-kinase/muscle subtype (PFK1-M), which also serves as the predominantly active PFK1 subtype in the pancreatic beta-cell. The fact that normal oscillatory secretion is impaired in subjects with impaired glucose tolerance and healthy relatives of patients with type 2 diabetes suggests that this defect may be involved in the secretory dysfunction. To evaluate a possible link between inherited PFK1-M deficiency in humans (Tarui's disease or glycogenosis type VII) and altered insulin oscillations, in vivo studies were performed. We determined basal insulin oscillations during 2 h of frequent plasma sampling in two related teen-aged individuals with homozygous and heterozygous PFK1-M deficiency compared with nondeficient, unrelated control subjects. As predicted by the underlying hypothesis, normal oscillations in insulin secretion were completely abolished in the individual with homozygous deficiency of PFK1-M and significantly impaired in the heterozygous individual, as shown by spectral density and autocorrelation analyses. Thus, deficiency of PFK1-M subtype in humans appears to be associated with an impaired oscillatory insulin secretion pattern and may contribute to the commonly observed secretion defects occurring in type 2 diabetes.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database