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HMG-1 as a late med...
HMG-1 as a late mediator of endotoxin lethality in mice
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Wang, HC (author)
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Bloom, O (author)
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Zhang, MH (author)
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Vishnubhakat, JM (author)
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Ombrellino, M (author)
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Che, JT (author)
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Frazier, A (author)
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Yang, H (author)
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Ivanova, S (author)
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Borovikova, L (author)
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Manogue, KR (author)
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Faist, E (author)
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Abraham, E (author)
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- Andersson, J (author)
- Karolinska Institutet
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- Andersson, U (author)
- Karolinska Institutet
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Molina, PE (author)
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Abumrad, NN (author)
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Sama, A (author)
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Tracey, KJ (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 1999
- 1999
- English.
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 285:5425, s. 248-251
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https://doi.org/10.1...
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Abstract
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- Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group–1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, HC
-
Bloom, O
-
Zhang, MH
-
Vishnubhakat, JM
-
Ombrellino, M
-
Che, JT
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show more...
-
Frazier, A
-
Yang, H
-
Ivanova, S
-
Borovikova, L
-
Manogue, KR
-
Faist, E
-
Abraham, E
-
Andersson, J
-
Andersson, U
-
Molina, PE
-
Abumrad, NN
-
Sama, A
-
Tracey, KJ
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show less...
- Articles in the publication
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Science (New Yor ...
- By the university
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Karolinska Institutet