onr:"swepub:oai:prod.swepub.kib.ki.se:1942703"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1942703" > CCR5 use by human i...
- 1 of 1
- Previous record
- Next record
- To hitlist
CCR5 use by human immunodeficiency virus type 1 is associated closely with the gp120 V3 loop N-linked glycosylation site
- Clevestig, P (author)
-
- Pramanik, L (author)
- Karolinska Institutet
- Leitner, T (author)
- show more...
- show less...
- (creator_code:org_t)
- Microbiology Society, 2006
- 2006
- English.
- In: The Journal of general virology. - : Microbiology Society. - 0022-1317 .- 1465-2099. ; 87:Pt 3, s. 607-612
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Human immunodeficiency virus type 1 (HIV-1) enters cells through the chemokine receptors CCR5 (R5 virus) and/or CXCR4 (X4 virus). Loss of N-linked glycans and increased net charge of the third variable loop (V3) of the gp120 envelope glycoprotein have been observed to be important steps towards CXCR4 use. All reported sequences using CCR5 or CXCR4 exclusively, or using both, were gathered from the Los Alamos HIV Database and analysed with regard to the V3 N-linked glycosylation motifs (sequons) and charge. The V3 loop glycan had a sensitivity of 0·98 and a 0·92 positive predictive value in the context of CCR5 use. The difference from X4 was remarkable (P<10−12). Especially, the sequon motif NNT within the V3 loop was conserved in 99·2 % of the major clades. The results suggest a close association between the V3 loop glycan and CCR5 use and may provide new insight into HIV-1 tropism and help to improve phenotype-prediction models.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- The Journal of general virology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Clevestig, P
- Pramanik, L
- Leitner, T
- Ehrnst, A
- Articles in the publication
- The Journal of g ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
