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Flow cytometric ana...
Flow cytometric analysis of BHRF1 expression prohibiting apoptosis induced by radiation
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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2016-06-29
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SAGE Publications,1999
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1942746
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1942746URI
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https://doi.org/10.1177/000348949910800511DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The Epstein-Barr virus gene BHRF1 has homology with proto-oncogene bcl-2, which can protect cells from apoptosis. In order to investigate the effect of BHRF1 expression on the anti-apoptotic ability of nasopharyngeal carcinoma (NPC) cells after irradiation, a high—BHRF1 expression vector was constructed and transfected into the NPC cell line CNE2. Then, the alteration of proliferation and apoptosis in the cells was tested by flow cytometry after cobalt 60 irradiation. The results showed that BHRF1 expression could increase G1 delay and decrease the cell percentage in S phase before irradiation, and reduce the apoptotic rate of CNE2 cells and increase the cell percentage in S phase after irradiation. The results suggest that BHRF1 expression is able to alter the cell cycle and protect CNE2 cells from apoptosis induced by radiation.
Added entries (persons, corporate bodies, meetings, titles ...)
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Pan, XH
(author)
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Zhou, SM
(author)
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Li, ZJ
(author)
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Yu, L
(author)
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Kong, XT
(author)
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Zheng, QP
(author)
Related titles
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In:The Annals of otology, rhinology, and laryngology: SAGE Publications108:5, s. 481-4840003-48941943-572X
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