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Expression of P-gly...
Expression of P-glycoprotein 170 in nasal mucosa may be increased with topical steroids
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- Henriksson, G (author)
- Karolinska Institutet
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Norlander, T (author)
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Zheng, X (author)
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- Stierna, P (author)
- Karolinska Institutet
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Westrin, KM (author)
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(creator_code:org_t)
- 2018-04-09
- 1997
- English.
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In: American journal of rhinology. - : SAGE Publications. - 1050-6586 .- 1539-6290. ; 11:4, s. 317-321
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https://doi.org/10.2...
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Abstract
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- The synthesis of P-glycoprotein 170 (P-gp), a “multidrug resistance” protein capable of extruding various drugs including 11-OH steroids from human cells, can be upregulated by certain glucocorticosteroids. This study demonstrates the presence of P-gp in the columnar surface epithelium and in glandular acini of healthy nasal mucosa with immunohistochemical technique. Furthermore, nasal polyps from 5 of 17 patients treated with clinical doses of a topical nasal steroid, budesonide, appear to show a stronger staining intensity for P-gp than polyps from 13 untreated patients. This suggests the possibility of local P-gp gene induction by topical glucocorticoid treatment. Upregulation of P-gp synthesis appears as a new possible cause of relative resistance to topical steroid medication in patients with nasal inflammatory disease.
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- ref (subject category)
- art (subject category)
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