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Functional changes ...
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Backman, LKarolinska Institutet
(author)
Functional changes in brain activity during priming in Alzheimer's disease
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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2000-01-01
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MIT Press - Journals,2000
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1949374
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1949374URI
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https://doi.org/10.1162/089892900561922DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Patients with Alzheimer's disease (AD) are often impaired on certain forms of implicit memory, such as word-stem completion priming (WSCP). Lesion data suggest that deficient WSCP may be associated with abnormal functioning in the posterior neocortex. Using positron emission tomography (PET), we here provide direct support for this view. Compared with normal old adults, AD patients showed reduced priming on a word-stem completion task. The normal old showed decreased activity in right occipital cortex (area 19), whereas the AD patients showed increased activity in this region during priming. To the extent that decreased activity during priming reflects an experience-dependent reduction of the neuronal population involved, these results indicate that shaping of the relevant neurons is slower in AD, possibly as a result of inadequate initial-stimulus processing.
Added entries (persons, corporate bodies, meetings, titles ...)
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Almkvist, OKarolinska Institutet
(author)
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Nyberg, L
(author)
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Andersson, J
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Journal of cognitive neuroscience: MIT Press - Journals12:1, s. 134-1410898-929X1530-8898
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