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Homocysteine, apoli...
Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment
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- Religa, D (author)
- Karolinska Institutet
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Styczynska, M (author)
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Peplonska, B (author)
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Gabryelewicz, T (author)
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Pfeffer, A (author)
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Chodakowska, M (author)
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Luczywek, E (author)
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Wasiak, B (author)
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Stepien, K (author)
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Golebiowski, M (author)
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- Winblad, B (author)
- Karolinska Institutet
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Barcikowska, M (author)
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(creator_code:org_t)
- 2003-06-10
- 2003
- English.
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In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 16:2, s. 64-70
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https://doi.org/10.1...
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Abstract
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- <i>Background:</i> Alzheimer’s disease (AD) is the most common dementia disorder in elderly people. Currently, the only known genetic factor associated with the development of sporadic AD is the apolipoprotein E (ApoE) 4 allele. There is a need to identify other environmental and genetic risk factors that could modulate the risk of developing sporadic AD. <i>Objective:</i> To analyse the correlation between the ApoE and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma homocysteine levels and vitamins (B<sub>12</sub> and folic acid) concentrations in serum from patients with AD and mild cognitive impairment (MCI) as compared with control group. <i>Methods:</i> The study was carried out in 99 AD patients, 98 subjects with MCI and 100 healthy subjects. Diagnosis of probable AD was made according to the NINCDS-ADRDA and DSM-IV criteria. The following factors were analysed: age, gender, duration of disease, concentration of plasma total homocysteine, folic acid and vitamin B<sub>12</sub> in the serum and the polymorphism of MTHRF and ApoE genes. The results obtained were analysed by multivariate analysis of regression. <i>Results:</i> We found that plasma total homocysteine is increased in AD patients (p < 0.0001) and depended on the MTHFR T/T genotype in the presence of low folate levels (p < 0.05). The increased frequency of ApoE4 allele in the AD population was independent of homocysteine, folic acid and vitamin B<sub>12</sub> levels and MTHFR status. <i>Conclusions:</i> We conclude that the concentration of plasma total homocysteine is increased in AD patients. This may be associated with the T/T genotype in the MTHFR gene; however, the distribution of the MTHRF C677T polymorphism in the Polish population does not differ in AD and controls.
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- art (subject category)
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- By the author/editor
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Religa, D
-
Styczynska, M
-
Peplonska, B
-
Gabryelewicz, T
-
Pfeffer, A
-
Chodakowska, M
-
show more...
-
Luczywek, E
-
Wasiak, B
-
Stepien, K
-
Golebiowski, M
-
Winblad, B
-
Barcikowska, M
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show less...
- Articles in the publication
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Dementia and ger ...
- By the university
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Karolinska Institutet