Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1951198" >
Inactivation of liv...
Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice
-
Andersson, S (author)
-
- Gustafsson, N (author)
- Karolinska Institutet
-
Warner, M (author)
-
show more...
-
- Gustafsson, JA (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2005-02-28
- 2005
- English.
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 102:10, s. 3857-3862
- Related links:
-
http://www.pnas.org/...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Male mice with inactivated liver X receptor (LXR) β suffer from adult-onset motor neuron degeneration. By 7 months of age, motor coordination is impaired, and this condition is associated with lipid accumulation and loss of motor neurons in the spinal cord, together with axonal atrophy and astrogliosis. Several of these features are reminiscent of the neuropathological signs of chronic motor neuron disease such as amyotrophic lateral sclerosis. Because the LXRs are important for cholesterol and lipid metabolism, we speculate that absence of LXRβ leads to pathological accumulation of sterols and lipids that may themselves be neurotoxic or may modulate intracellular pathways and thereby predispose motor neurons to degeneration.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database