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Direct NK cell-medi...
Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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The American Association of Immunologists,2000
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1952972
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1952972URI
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https://doi.org/10.4049/jimmunol.165.9.4895DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In contrast to extensive studies on the role of T and B lymphocytes in the pathogenesis of autoimmune diseases of the nervous system, little is known about NK cells and their potential role in the destruction of neural tissue. NK cells have been implicated in the selective death of sympathetic neurons resident in the superior cervical ganglia of rats after exposure to the drug guanethidine. This observation suggests that NK cells may function as principle effectors in immunological diseases of the nervous system. However, the direct mechanism of action of NK cells in this model is not known. In particular, it is not known whether NK cells can kill autologous neurons directly. The aim of the present study was to examine whether NK cells can kill directly dorsal root ganglia neurons cultured in vitro. We demonstrate that C57BL/6 (B6)-derived dorsal root ganglia neurons can be killed directly by syngenic IL-2-activated NK cells, and that this nerve cell lysis is dependent on the expression of perforin in the NK cells. NK cells were less effective in destroying neurons grown in the presence of glial cells. These observations indicate a potential role for NK cells in nerve cell degeneration in inflammatory diseases of the nervous system.
Added entries (persons, corporate bodies, meetings, titles ...)
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Chambers, BJKarolinska Institutet
(author)
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Kristensson, KKarolinska Institutet
(author)
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Ljunggren, HGKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Journal of immunology (Baltimore, Md. : 1950): The American Association of Immunologists165:9, s. 4895-49000022-17671550-6606
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