onr:"swepub:oai:prod.swepub.kib.ki.se:1954180"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1954180" > Immunization with r...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02996naa a2200361 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1954180 | |
| 003 | SwePub | |
| 008 | 240701s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19541802 URI |
| 024 | 7 | a https://doi.org/10.1099/0022-1317-83-4-8072 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nilsson, Cu Karolinska Institutet4 aut |
| 245 | 1 0 | a Immunization with recombinant modified vaccinia virus Ankara can modify mucosal simian immunodeficiency virus infection and delay disease progression in macaques |
| 264 | 1 | b Microbiology Society,c 2002 |
| 520 | a In the present study, the immunogenicity and protective efficacy of a recombinant vaccinia virus-based simian immunodeficiency virus (SIV) vaccine, given alone or in combination with a protein boost, were investigated. Cynomolgus macaques were immunized intramuscularly with modified vaccinia virus Ankara (MVA) expressing the SIVsmenvandgag–polgenes (MVA–SIVsm) at 0 and 3 months (n=4), at 0, 3 and 8 months (n=4) or at 0 and 3 months followed by purified native SIVsm gp148 and recombinant SIVmac p27 in immunostimulatory complexes at 8 months (n=4). One month after the last immunization, the vaccinees, together with four naive control monkeys and four monkeys immunized with wild-type MVA, were challenged intrarectally with 10 MID50SIVsm. At the time of challenge, antibody titres to SIV Env and lymphocyte proliferation responses to whole viral antigen were highest in vaccinees receiving MVA–SIVsm in combination with protein immunizations. Following rectal challenge, one of these vaccinees was completely protected. A prolonged survival time was observed in two of four monkeys in each of the groups immunized with MVA–SIVsm, in two monkeys given MVA–SIVsm followed by protein and in three of four monkeys given wild-type MVA, compared with naive controls. In conclusion, one monkey given the combined vaccine was protected completely against SIVsm infection. Furthermore, immunization with MVA–SIVsm, as well as wild-type MVA alone, seemed to delay disease progression after mucosal SIV infection in a proportion of the monkeys. | |
| 700 | 1 | a Sutter, G4 aut |
| 700 | 1 | a Walther-Jallow, L4 aut |
| 700 | 1 | a ten Haaft, P4 aut |
| 700 | 1 | a Akerblom, L4 aut |
| 700 | 1 | a Heeney, J4 aut |
| 700 | 1 | a Erfle, V4 aut |
| 700 | 1 | a Bottiger, P4 aut |
| 700 | 1 | a Biberfeld, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Thorstensson, R4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The Journal of general virologyd : Microbiology Societyg 83:Pt 4, s. 807-818q 83:Pt 4<807-818x 0022-1317x 1465-2099 |
| 856 | 4 | u https://doi.org/10.1099/0022-1317-83-4-807 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1954180 |
| 856 | 4 8 | u https://doi.org/10.1099/0022-1317-83-4-807 |
Find in a library
- The Journal of general virology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nilsson, C
- Sutter, G
- Walther-Jallow, ...
- ten Haaft, P
- Akerblom, L
- Heeney, J
- show more...
- Erfle, V
- Bottiger, P
- Biberfeld, G
- Thorstensson, R
- show less...
- Articles in the publication
- The Journal of g ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
