Search: onr:"swepub:oai:prod.swepub.kib.ki.se:1958414" >
The neuropeptide Y/...
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
-
- Broberger, C (author)
- Karolinska Institutet
-
- Johansen, J (author)
- Karolinska Institutet
-
- Johansson, C (author)
- Karolinska Institutet
-
show more...
-
- Schalling, M (author)
- Karolinska Institutet
-
- Hokfelt, T (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 1998-12-08
- 1998
- English.
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 95:25, s. 15043-15048
- Related links:
-
https://www.ncbi.nlm...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Neuropeptide Y (NPY) and the endogenous melanocortin receptor antagonist, agouti gene-related protein (AGRP), coexist in the arcuate nucleus, and both exert orexigenic effects. The present study aimed primarily at determining the brain distribution of AGRP. AGRP mRNA-expressing cells were limited to the arcuate nucleus, representing a major subpopulation (95%) of the NPY neurons, which also was confirmed with immunohistochemistry. AGRP-immunoreactive (-ir) terminals all contained NPY and were observed in many brain regions extending from the rostral telencephalon to the pons, including the parabrachial nucleus. NPY-positive, AGRP-negative terminals were observed in many areas. AGRP-ir terminals were reduced dramatically in all brain regions of mice treated neonatally with monosodium glutamate as well as of mice homozygous for the anorexia mutation. Terminals immunoreactive for the melanocortin peptide α-melanocyte-stimulating hormone formed a population separate from, but parallel to, the AGRP-ir terminals. Our results show that arcuate NPY neurons, identified by the presence of AGRP, project more extensively in the brain than previously known and indicate that the feeding regulatory actions of NPY may extend beyond the hypothalamus.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database