onr:"swepub:oai:prod.swepub.kib.ki.se:217119697"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:217119697" > Investigation of po...
- 1 of 1
- Previous record
- Next record
- To hitlist
Investigation of possible association between Ser9Gly polymorphism of the D3 dopaminergic receptor gene and response to typical antipsychotics in patients with schizophrenia
- Cordeiro, Q (author)
- Miguita, K (author)
- Miracca, E (author)
- show more...
- Elkis, H (author)
- show less...
- (creator_code:org_t)
- FapUNIFESP (SciELO), 2006
- 2006
- English.
- In: Sao Paulo medical journal = Revista paulista de medicina. - : FapUNIFESP (SciELO). - 1516-3180. ; 124:3, s. 165-7
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Typical antipsychotics have a high affinity for dopamine receptors. It is therefore of interest to investigate such loci in pharmacogenetic studies on psychosis. We investigated the hypothesis that Ser9Gly polymorphism of the DRD3 gene may play a role in the differences in individual response to typical antipsychotics between schizophrenic patients. The sample was composed of 53 good responders and 59 poor ones. No significant differences between the good and poor responders were found in the allelic distribution (good responders: Ser9 61.32%, Gly9 38.67%; poor responders: Ser9 64.40%, Gly9 35.59%; odds ratio, OR = 0.88, 0.49 < OR < 1.56; chi2 = 0.23, 1 degree of freedom, df, p = 0.63) and genotype distribution (good responders: Ser9/Ser9 37.73%, Ser9/Gly9 47.16%, Gly9/Gly9 15.09%; poor responders: Ser9/Ser9 42.37%, Ser9/Gly9 44.06%, Gly9/Gly9 13.55%; chi2 = 0.25, 2 df, p = 0.88). Nor was there any association with homozygosity (good responders: homozygous: 52.82%, heterozygous: 47.16%; poor responders: homozygous: 55.92%, heterozygous: 44.06%; odds ratio, OR = 0.88, 0.39 < OR < 1.99; chi2 = 0.11, 1 df, p = 0.74). The results did not support the hypothesis that Ser9Gly polymorphism of the DRD3 gene influences the response to typical antipsychotics in our sample of schizophrenics.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Sao Paulo medical journal = Revista paulista de medicina (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Cordeiro, Q
- Miguita, K
- Miracca, E
- Elkis, H
- Vallada, H
- Articles in the publication
- Sao Paulo medica ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
