Search: onr:"swepub:oai:prod.swepub.kib.ki.se:227831918" >
17β-Estradiol suppr...
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Al-Qahtani, SMKarolinska Institutet
(author)
17β-Estradiol suppresses visceral adipogenesis and activates brown adipose tissue-specific gene expression
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Walter de Gruyter GmbH,2017
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:227831918
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http://kipublications.ki.se/Default.aspx?queryparsed=id:227831918URI
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https://doi.org/10.1515/hmbci-2016-0031DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice. This loss of adiposity was associated with diminished visceral adipocyte size and reductions in expression of lipogenic genes, adipokines and of the nuclear receptor
Added entries (persons, corporate bodies, meetings, titles ...)
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Bryzgalova, GKarolinska Institutet
(author)
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Valladolid-Acebes, IKarolinska Institutet
(author)
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Korach-André, MKarolinska Institutet
(author)
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Dahlman-Wright, K
(author)
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Efendić, S
(author)
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Berggren, PO
(author)
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Portwood, N
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Hormone molecular biology and clinical investigation: Walter de Gruyter GmbH29:1, s. 13-261868-18911868-1883
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