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Serum complexed and...
Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women
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- Eklund, E (author)
- Karolinska Institutet
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Diamandis, EP (author)
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Muytjens, C (author)
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Wheeler, S (author)
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Mathew, A (author)
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Stengelin, M (author)
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Glezer, E (author)
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Nikolenko, G (author)
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Brown, MD (author)
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Zheng, Y (author)
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- Hirschberg, AL (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-07-17
- 2017
- English.
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In: F1000Research. - : F1000 Research Ltd. - 2046-1402. ; 6, s. 1131-
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Abstract
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- Background: We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women.Methods: We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls. Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively. A panel of estrogens, androgens and progesterone in the same serum was also quantified by tandem mass spectrometry. Results: Both components of serum PSA (cPSA and fPSA) were lower in the elite athletes vs the control group (P=0.033 and 0.013, respectively). Furthermore, estrone (p=0.003) and estradiol (p=0.004) were significantly lower, and dehydroepiandrosterone (p=0.095) and 5-androstene-3β, 17β-diol (p=0.084) tended to be higher in the athletes vs controls. Oral contraceptive use was similar between groups and significantly associated with increased cPSA and fPSA in athletes (p= 0.046 and 0.009, respectively). PSA fractions were not significantly associated with progesterone changes. The Spearman correlation between cPSA and fPSA in both athletes and controls was 0.75 (P < 0.0001) and 0.64 (P < 0.0001), respectively. Conclusions: Elite athletes have lower complexed and free PSA, higher levels of androgen precursors and lower levels of estrogen in their serum than sedentary control women.Abbreviations: cPSA, complexed PSA; fPSA, free PSA; PCOS, polycystic ovarian syndrome; E1, estrone; E2, estradiol; DHEA, dehydroepiandrosterone, Testo, testosterone; DHT, dihydrotestosterone; PROG, progesterone; Delta 4, androstenedione; Delta 5, androst-5-ene-3β, 17β-diol; BMD, body mineral density; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; LOD, limit of detection; ACT, α1-antichymotrypsin
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- art (subject category)
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- By the author/editor
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Eklund, E
-
Diamandis, EP
-
Muytjens, C
-
Wheeler, S
-
Mathew, A
-
Stengelin, M
-
show more...
-
Glezer, E
-
Nikolenko, G
-
Brown, MD
-
Zheng, Y
-
Hirschberg, AL
-
show less...
- Articles in the publication
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F1000Research
- By the university
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Karolinska Institutet