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Altered Fc galactos...
Altered Fc galactosylation in IgG4 is a potential serum marker for chronic lung disease
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-07-31
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European Respiratory Society (ERS),2018
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:230083550
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http://kipublications.ki.se/Default.aspx?queryparsed=id:230083550URI
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https://doi.org/10.1183/23120541.00033-2018DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Characterising chronic lung diseases is challenging. New, less invasive diagnostics are needed to decipher disease pathologies and subphenotypes. Fc galactosylation is known to affect IgG function, and is altered in autoimmune disorders and under other pathological conditions. We tested how well Fc glycans in IgG from bronchoalveolar lavage fluid (BALF) and serum correlated, and if the Fc glycan profile could reveal pulmonary inflammation.A shotgun proteomics approach was used to profile Fc glycans in serum and BALF of controls (n=12) and sarcoidosis phenotypes (Löfgren's syndrome (LS), n=11; and non-LS, n=12). Results were further validated in severe asthma (SA) (n=20) and published rheumatoid arthritis (RA) patient data (n=13) including clinical information.Intra-individually, Fc-galactosylation status of IgG1 (R2=0.87) and IgG4 (R2=0.95) correlated well between matrixes. Following GlycoAge-index correction, the ratio between agalactosylated and digalactosylated Fc glycans of IgG4 could distinguish sarcoidosis and SA from healthy and RA subjects with a mean±se area under the curve (AUC) of 78±6%. The AUC increased to 83±6% using the more chronic lung disease types (non-LS and SA) and most strikingly, to 87±6% for the SA subgroup.The results indicate that the Fc galactosylation status of IgG4 is a potential blood test marker for chronic lung inflammation.
Added entries (persons, corporate bodies, meetings, titles ...)
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Wiklundh, EKarolinska Institutet
(author)
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Eklund, AKarolinska Institutet
(author)
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James, AKarolinska Institutet
(author)
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Grunewald, JKarolinska Institutet
(author)
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Zubarev, RAKarolinska Institutet
(author)
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Lundström, SLKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:ERJ open research: European Respiratory Society (ERS)4:32312-0541
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