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Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases
- Al-Majid, A (author)
- Alassiri, S (author)
- Rathnayake, N (author)
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- Tervahartiala, T (author)
- Gieselmann, DR (author)
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- (creator_code:org_t)
- Hindawi Limited, 2018
- 2018
- English.
- In: International journal of dentistry. - : Hindawi Limited. - 1687-8728 .- 1687-8736. ; 2018, s. 7891323-
- Journal article (peer-reviewed)
Abstract
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- Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with other proinflammatory and/or microbiological biomarkers.
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- Alassiri, S
- Rathnayake, N
- Tervahartiala, T
- Gieselmann, DR
- Sorsa, T
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