The best COVID-19 predictor is recent smell loss: a cross-sectional study

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Gerkin, RC (author)

The best COVID-19 predictor is recent smell loss: a cross-sectional study

Article/chapterEnglish2020

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Cold Spring Harbor Laboratory,2020

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:232743605
http://kipublications.ki.se/Default.aspx?queryparsed=id:232743605URI
https://doi.org/10.1101/2020.07.22.20157263DOI

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Language:English
Summary in:English

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BackgroundCOVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19.MethodsThis preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery.ResultsBoth C19+ and C19-groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ∼50% of participants and was best predicted by time since illness onset.ConclusionsAs smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4<OR<10), which can be deployed when viral lab tests are impractical or unavailable.

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Ohla, K (author)
Veldhuizen, MG (author)
Joseph, PV (author)
Kelly, CE (author)
Bakke, AJ (author)
Steele, KE (author)
Farruggia, MC (author)
Pellegrino, R (author)
Pepino, MY (author)
Bouysset, C (author)
Soler, GM (author)
Pereda-Loth, V (author)
Dibattista, M (author)
Cooper, KW (author)
Croijmans, I (author)
Di Pizio, A (author)
Ozdener, MH (author)
Fjaeldstad, AW (author)
Lin, C (author)
Sandell, MA (author)
Singh, PB (author)
Brindha, VE (author)
Olsson, SB (author)
Saraiva, LR (author)
Ahuja, G (author)
Alwashahi, MK (author)
Bhutani, S (author)
D'Errico, A (author)
Fornazieri, MA (author)
Golebiowski, J (author)
Hwang, LD (author)
Öztürk, L (author)
Roura, E (author)
Spinelli, S (author)
Whitcroft, KL (author)
Faraji, F (author)
Fischmeister, FPS (author)
Heinbockel, T (author)
Hsieh, JW (author)
Huart, C (author)
Konstantinidis, I (author)
Menini, A (author)
Morini, G (author)
Olofsson, JK (author)
Philpott, CM (author)
Pierron, D (author)
Shields, VDC (author)
Voznessenskaya, VV (author)
Albayay, J (author)
Altundag, A (author)
Bensafi, M (author)
Bock, MA (author)
Calcinoni, O (author)
Fredborg, W (author)
Laudamiel, C (author)
Lim, J (author)
Lundström, JNKarolinska Institutet (author)
Macchi, A (author)
Meyer, P (author)
Moein, ST (author)
Santamaría, E (author)
Sengupta, D (author)
Domínguez, PP (author)
Yanık, H (author)
Boesveldt, S (author)
de Groot, JHB (author)
Dinnella, C (author)
Freiherr, J (author)
Laktionova, T (author)
Mariño, S (author)
Monteleone, E (author)
Nunez-Parra, A (author)
Abdulrahman, O (author)
Ritchie, M (author)
Thomas-Danguin, T (author)
Walsh-Messinger, J (author)
Al Abri, R (author)
Alizadeh, R (author)
Bignon, E (author)
Cantone, E (author)
Cecchini, MP (author)
Chen, J (author)
Guàrdia, MD (author)
Hoover, KC (author)
Karni, N (author)
Navarro, M (author)
Nolden, AA (author)
Mazal, PP (author)
Rowan, NR (author)
Sarabi-Jamab, A (author)
Archer, NS (author)
Chen, B (author)
Di Valerio, EA (author)
Feeney, EL (author)
Frasnelli, J (author)
Hannum, M (author)
Hopkins, C (author)
Klein, H (author)
Mignot, C (author)
Mucignat, C (author)
Ning, Y (author)
Ozturk, EE (author)
Peng, M (author)
Saatci, O (author)
Sell, EA (author)
Yan, CH (author)
Alfaro, R (author)
Cecchetto, C (author)
Coureaud, G (author)
Herriman, RD (author)
Justice, JM (author)
Kaushik, PK (author)
Koyama, S (author)
Overdevest, JB (author)
Pirastu, N (author)
Ramirez, VA (author)
Roberts, SC (author)
Smith, BC (author)
Cao, H (author)
Wang, H (author)
Balungwe, P (author)
Baguma, M (author)
Hummel, T (author)
Hayes, JE (author)
Reed, DR (author)
Niv, MY (author)
Munger, SD (author)
Parma, V (author)
Karolinska Institutet (creator_code:org_t)

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By the author/editor: Gerkin, RC; Ohla, K; Veldhuizen, MG; Joseph, PV; Kelly, CE; Bakke, AJ; show more...; Steele, KE; Farruggia, MC; Pellegrino, R; Pepino, MY; Bouysset, C; Soler, GM; Pereda-Loth, V; Dibattista, M; Cooper, KW; Croijmans, I; Di Pizio, A; Ozdener, MH; Fjaeldstad, AW; Lin, C; Sandell, MA; Singh, PB; Brindha, VE; Olsson, SB; Saraiva, LR; Ahuja, G; Alwashahi, MK; Bhutani, S; D'Errico, A; Fornazieri, MA; Golebiowski, J; Hwang, LD; Öztürk, L; Roura, E; Spinelli, S; Whitcroft, KL; Faraji, F; Fischmeister, FP ...; Heinbockel, T; Hsieh, JW; Huart, C; Konstantinidis, ...; Menini, A; Morini, G; Olofsson, JK; Philpott, CM; Pierron, D; Shields, VDC; Voznessenskaya, ...; Albayay, J; Altundag, A; Bensafi, M; Bock, MA; Calcinoni, O; Fredborg, W; Laudamiel, C; Lim, J; Lundström, JN; Macchi, A; Meyer, P; Moein, ST; Santamaría, E; Sengupta, D; Domínguez, PP; Yanık, H; Boesveldt, S; de Groot, JHB; Dinnella, C; Freiherr, J; Laktionova, T; Mariño, S; Monteleone, E; Nunez-Parra, A; Abdulrahman, O; Ritchie, M; Thomas-Danguin, ...; Walsh-Messinger, ...; Al Abri, R; Alizadeh, R; Bignon, E; Cantone, E; Cecchini, MP; Chen, J; Guàrdia, MD; Hoover, KC; Karni, N; Navarro, M; Nolden, AA; Mazal, PP; Rowan, NR; Sarabi-Jamab, A; Archer, NS; Chen, B; Di Valerio, EA; Feeney, EL; Frasnelli, J; Hannum, M; Hopkins, C; Klein, H; Mignot, C; Mucignat, C; Ning, Y; Ozturk, EE; Peng, M; Saatci, O; Sell, EA; Yan, CH; Alfaro, R; Cecchetto, C; Coureaud, G; Herriman, RD; Justice, JM; Kaushik, PK; Koyama, S; Overdevest, JB; Pirastu, N; Ramirez, VA; Roberts, SC; Smith, BC; Cao, H; Wang, H; Balungwe, P; Baguma, M; Hummel, T; Hayes, JE; Reed, DR; Niv, MY; Munger, SD; Parma, V; show less...

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