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Factors Affecting t...
Factors Affecting the Control of Chronic Rhinosinusitis With Nasal Polyps: A Comparison in Patients With or Without NERD
- Article/chapterEnglish2021
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2021-04-26
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SAGE Publications,2021
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:233996192
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http://kipublications.ki.se/Default.aspx?queryparsed=id:233996192URI
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https://doi.org/10.1177/21526567211003844DOI
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
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The aim was to compare the control of chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS), in patients with/without nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). Study Desing: A retrospective hospital-based sample of CRSwNP patients with/without NERD with follow-up. Setting Tertiary rhinology centers. Methods Electronic patient record data from 116 CRSwNP patients (46 with NERD and 70 without NERD) undergoing ESS during 2001–17 were studied. Mean follow-up time was 9.9 years (range 1.1–15.3). Endpoints reflecting uncontrolled CRSwNP were revision ESS, and need for rescue/advanced therapy (e.g. antibiotics, oral corticosteroids and/or biological therapy) during follow-up. NERD was variable of interest and gender, age, asthma, allergic rhinitis (AR), smoking, Lund-Mackay (LM) score of sinus computed tomography scans previous ESS and baseline total ethmoidectomy were used as covariates. Results Twenty-one (49.7%) NERD patients and 18 (25.7%) non-NERD patients underwent revision ESS within a mean ± SD of 4.3 ± 2.8 and 3.7 ± 2.6 years, respectively (p = .013, by Logrank test). In Cox´s regression models, NERD, female gender, young age, asthma, AR, previous ESS, and lack of total ethmoidectomy were associated with revision-ESS. In adjusted model, only the total ethmoidectomy predicted revision-free survival. In adjusted logistic regression model, there was an insignificant trend that NERD and LM score were associated with the need for rescue/advanced therapy in the follow-up. Conclusions Patients with NERD had higher risk of uncontrolled CRSwNP than patient group without NERD, as measured by revision ESS and/or need for rescue/advanced therapy in the follow-up. In addition, baseline total ethmoidectomy was associated with revision-free survival.
Added entries (persons, corporate bodies, meetings, titles ...)
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Koskinen, A
(author)
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Virkkula, P
(author)
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Vento, SI
(author)
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Myller, J
(author)
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Hammarén-Malmi, S
(author)
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Laulajainen-Hongisto, A
(author)
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Hytönen, M
(author)
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Mäkitie, AKarolinska Institutet
(author)
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Numminen, J
(author)
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Sillanpää, S
(author)
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Raitiola, H
(author)
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Rautiainen, M
(author)
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Toppila-Salmi, SK
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Allergy & rhinology (Providence, R.I.): SAGE Publications12, s. 21526567211003844-2152-65752152-6567
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Lilja, MJ
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Koskinen, A
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Virkkula, P
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Vento, SI
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Myller, J
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Laulajainen-Hong ...
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Hytönen, M
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Mäkitie, A
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Sillanpää, S
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Raitiola, H
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Rautiainen, M
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Karolinska Institutet