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Indocyanine Green-A...
Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque
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Nikinmaa, S (author)
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Moilanen, N (author)
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- Sorsa, T (author)
- Karolinska Institutet
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Rantala, J (author)
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Alapulli, H (author)
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Kotiranta, A (author)
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Auvinen, P (author)
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Kankuri, E (author)
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Meurman, JH (author)
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Pätilä, T (author)
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(creator_code:org_t)
- 2021-05-03
- 2021
- English.
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In: Dentistry journal. - : MDPI AG. - 2304-6767. ; 9:5
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Aim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque. Methods: Fifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm2 of 810 nm LED light was applied to the aPDT-treatment area. Plaque area and gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) were measured, and plaque bacteriomes before and after the study were analyzed using 16S rRNA sequencing. Results: aPDT administration was preformed successfully and plaque-specifically with the combination of ICG and the applicator. Total plaque area and endpoint MMP-8 levels were reduced on the aPDT-treatment side. aPDT reduced Streptococcus, Acinetobacteria, Capnocytophaga, and Rothia bacteria species in plaques. Conclusion: ICG-assisted aPDT reduces plaque forming bacteria and exerts anti-inflammatory and anti-proteolytic effects.
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- art (subject category)
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- By the author/editor
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Nikinmaa, S
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Moilanen, N
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Sorsa, T
-
Rantala, J
-
Alapulli, H
-
Kotiranta, A
-
show more...
-
Auvinen, P
-
Kankuri, E
-
Meurman, JH
-
Pätilä, T
-
show less...
- Articles in the publication
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Dentistry journa ...
- By the university
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Karolinska Institutet