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A bispecific monome...
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Hanke, LKarolinska Institutet
(author)
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-10
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:235013189
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http://kipublications.ki.se/Default.aspx?queryparsed=id:235013189URI
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https://doi.org/10.1038/s41467-021-27610-zDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155232845URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the isolation of a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer–dimers leading to the loss of their ability to attach to the host cell receptor, ACE2. We show that this nanobody potently neutralizes SARS-CoV-2, including the beta and delta variants, and cross-neutralizes SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against SARS-CoV-2 and the beta variant in a human ACE2 transgenic mouse model. This naturally elicited bispecific monomeric nanobody establishes an uncommon strategy for potent inactivation of viral antigens and represents a promising antiviral against emerging SARS-CoV-2 variants.
Added entries (persons, corporate bodies, meetings, titles ...)
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Das, HKarolinska Institutet
(author)
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Sheward, DJKarolinska Institutet
(author)
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Perez Vidakovics, LKarolinska Institutet
(author)
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Urgard, EKarolinska Institutet
(author)
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Moliner-Morro, AKarolinska Institutet
(author)
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Kim, CKarolinska Institutet
(author)
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Karl, V
(author)
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Pankow, A
(author)
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Smith, NL
(author)
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Porebski, BKarolinska Institutet
(author)
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Fernandez-Capetillo, OKarolinska Institutet
(author)
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Sezgin, EKarolinska Institutet
(author)
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Pedersen, GK
(author)
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Coquet, JMKarolinska Institutet
(author)
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Hällberg, BMKarolinska Institutet
(author)
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Murrell, BKarolinska Institutet
(author)
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McInerney, GMKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC13:1, s. 155-2041-1723
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Hanke, L
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Das, H
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Sheward, DJ
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Perez Vidakovics ...
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Urgard, E
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Moliner-Morro, A
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Kim, C
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Karl, V
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Pankow, A
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Smith, NL
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Porebski, B
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Fernandez-Capeti ...
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Sezgin, E
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Pedersen, GK
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Coquet, JM
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Hällberg, BM
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Murrell, B
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McInerney, GM
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Karolinska Institutet