Search: onr:"swepub:oai:prod.swepub.kib.ki.se:235757444" >
aMMP-8 Oral Fluid P...
-
Sorsa, TKarolinska Institutet
(author)
aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-06-10
-
Frontiers Media SA,2022
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:235757444
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:235757444URI
-
https://doi.org/10.3389/froh.2022.897115DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Nwhator, SO
(author)
-
Sakellari, D
(author)
-
Grigoriadis, A
(author)
-
Umeizudike, KA
(author)
-
Brandt, E
(author)
-
Keskin, M
(author)
-
Tervahartiala, T
(author)
-
Pärnänen, P
(author)
-
Gupta, S
(author)
-
Mohindra, R
(author)
-
Bostanci, NKarolinska Institutet
(author)
-
Buduneli, N
(author)
-
Räisänen, IT
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Frontiers in oral health: Frontiers Media SA3, s. 897115-2673-4842
Internet link
Find in a library
To the university's database
- By the author/editor
-
Sorsa, T
-
Nwhator, SO
-
Sakellari, D
-
Grigoriadis, A
-
Umeizudike, KA
-
Brandt, E
-
show more...
-
Keskin, M
-
Tervahartiala, T
-
Pärnänen, P
-
Gupta, S
-
Mohindra, R
-
Bostanci, N
-
Buduneli, N
-
Räisänen, IT
-
show less...
- Articles in the publication
-
Frontiers in ora ...
- By the university
-
Karolinska Institutet