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- Sorsa, TKarolinska Institutet (author)
aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-06-10
- Frontiers Media SA,2022
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:235757444
- http://kipublications.ki.se/Default.aspx?queryparsed=id:235757444URI
- https://doi.org/10.3389/froh.2022.897115DOI
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- Language:English
- Summary in:English
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- The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.
Added entries (persons, corporate bodies, meetings, titles ...)
- Nwhator, SO (author)
- Sakellari, D (author)
- Grigoriadis, A (author)
- Umeizudike, KA (author)
- Brandt, E (author)
- Keskin, M (author)
- Tervahartiala, T (author)
- Pärnänen, P (author)
- Gupta, S (author)
- Mohindra, R (author)
- Bostanci, NKarolinska Institutet (author)
- Buduneli, N (author)
- Räisänen, IT (author)
- Karolinska Institutet (creator_code:org_t)
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- In:Frontiers in oral health: Frontiers Media SA3, s. 897115-2673-4842
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