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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02963naa a2200409 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:235757444 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2357574442 URI |
| 024 | 7 | a https://doi.org/10.3389/froh.2022.8971152 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Sorsa, Tu Karolinska Institutet4 aut |
| 245 | 1 0 | a aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases |
| 264 | c 2022-06-10 | |
| 264 | 1 | b Frontiers Media SA,c 2022 |
| 520 | a The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology. | |
| 700 | 1 | a Nwhator, SO4 aut |
| 700 | 1 | a Sakellari, D4 aut |
| 700 | 1 | a Grigoriadis, A4 aut |
| 700 | 1 | a Umeizudike, KA4 aut |
| 700 | 1 | a Brandt, E4 aut |
| 700 | 1 | a Keskin, M4 aut |
| 700 | 1 | a Tervahartiala, T4 aut |
| 700 | 1 | a Pärnänen, P4 aut |
| 700 | 1 | a Gupta, S4 aut |
| 700 | 1 | a Mohindra, R4 aut |
| 700 | 1 | a Bostanci, Nu Karolinska Institutet4 aut |
| 700 | 1 | a Buduneli, N4 aut |
| 700 | 1 | a Räisänen, IT4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Frontiers in oral healthd : Frontiers Media SAg 3, s. 897115-q 3<897115-x 2673-4842 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:235757444 |
| 856 | 4 8 | u https://doi.org/10.3389/froh.2022.897115 |
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