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Home-Applied Dual-L...
Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)-Three-Month Interim Results
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Pakarinen, S (author)
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Saarela, RKT (author)
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Välimaa, H (author)
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Heikkinen, AM (author)
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Kankuri, E (author)
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Noponen, M (author)
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Alapulli, H (author)
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Tervahartiala, T (author)
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Räisänen, IT (author)
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- Sorsa, T (author)
- Karolinska Institutet
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Pätilä, T (author)
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(creator_code:org_t)
- 2022-11-02
- 2022
- English.
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In: Dentistry journal. - : MDPI AG. - 2304-6767. ; 10:11
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- A single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral® dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including standardized hygiene instructions and electric toothbrush, scaling and root planing, or NSPT with adjunctive Lumoral® treatment. A complete clinical intraoral examination was conducted in the beginning, at three months, and at six months. This report presents the three-month results of the first 59 consecutive randomized subjects. At three months, bleeding on probing (BOP) was lower in the NSPT + Lumoral®-group than in the NSPT group (p = 0.045), and more patients in the NSPT + Lumoral®-group had their BOP below 10% (54% vs. 22%, respectively, p = 0.008). In addition, patients in the NSPT + Lumoral®-group improved their oral hygiene by visible-plaque-index (p = 0.0003), while the NSPT group showed no statistical improvement compared to the baseline. Both groups significantly reduced the number of deep periodontal pockets, but more patients with a reduction in their deep pocket number were found in the NSPT + Lumoral® group (92% vs. 63%, p = 0.02). Patients whose number of deep pockets was reduced by 50% or more were also more frequent in the NSPT + Lumoral®-group (71% vs. 33%, p = 0.01). Patients with initially less than ten deep pockets had fewer deep pockets at the three-month follow-up in the Lumoral® group (p = 0.01). In conclusion, adjunctive use of Lumoral® in NSPT results in improved treatment outcomes at three months post-therapy.
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- art (subject category)
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- By the author/editor
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Pakarinen, S
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Saarela, RKT
-
Välimaa, H
-
Heikkinen, AM
-
Kankuri, E
-
Noponen, M
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show more...
-
Alapulli, H
-
Tervahartiala, T
-
Räisänen, IT
-
Sorsa, T
-
Pätilä, T
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show less...
- Articles in the publication
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Dentistry journa ...
- By the university
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Karolinska Institutet