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GPR55 in B cells li...
GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation
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Guillamat-Prats, R (author)
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Hering, D (author)
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Derle, A (author)
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Rami, M (author)
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Härdtner, C (author)
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Santovito, D (author)
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Rinne, P (author)
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Bindila, L (author)
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Hristov, M (author)
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Pagano, S (author)
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Vuilleumier, N (author)
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Schmid, S (author)
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Janjic, A (author)
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Enard, W (author)
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Weber, C (author)
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- Maegdefessel, L (author)
- Karolinska Institutet
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Faussner, A (author)
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Hilgendorf, I (author)
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Steffens, S (author)
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(creator_code:org_t)
- 2022-11-11
- 2022
- English.
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In: Nature cardiovascular research. - : Springer Science and Business Media LLC. - 2731-0590. ; 1, s. 1056-1071
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Abstract
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- Dissecting the pathways regulating the adaptive immune response in atherosclerosis is of particular therapeutic interest. Here we report that the lipid G-protein-coupled receptor GPR55 is highly expressed by splenic plasma cells (PCs), upregulated in mouse spleens during atherogenesis and human unstable or ruptured compared to stable plaques.Gpr55-deficient mice developed larger atherosclerotic plaques with increased necrotic core size compared to their corresponding controls. Lack of GPR55 hyperactivated B cells, disturbed PC maturation and resulted in IgG overproduction. B-cell-specificGpr55depletion or adoptive transfer ofGpr55-deficient B cells was sufficient to promote plaque development and elevated IgG titers. In vitro, the endogenous GPR55 ligand lysophsophatidylinositol (LPI) enhanced PC proliferation, whereas GPR55 antagonism blocked PC maturation and increased their mitochondrial content. Collectively, these discoveries provide previously undefined evidence for GPR55 in B cells as a key modulator of the adaptive immune response in atherosclerosis.
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- By the author/editor
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Guillamat-Prats, ...
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Hering, D
-
Derle, A
-
Rami, M
-
Härdtner, C
-
Santovito, D
-
show more...
-
Rinne, P
-
Bindila, L
-
Hristov, M
-
Pagano, S
-
Vuilleumier, N
-
Schmid, S
-
Janjic, A
-
Enard, W
-
Weber, C
-
Maegdefessel, L
-
Faussner, A
-
Hilgendorf, I
-
Steffens, S
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show less...
- Articles in the publication
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Nature cardiovas ...
- By the university
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Karolinska Institutet