Search: onr:"swepub:oai:prod.swepub.kib.ki.se:236909636" >
Modeling of Intrace...
Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection
- Article/chapterEnglish2024
Publisher, publication year, extent ...
-
Cold Spring Harbor Laboratory,2024
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:236909636
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:236909636URI
-
https://doi.org/10.1101/2023.02.24.529893DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:vet swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are needed. We have profiled ascites as OC tumor microenvironments (TMs) to search for potential components that would exert growth suppression on OC cell cultures. Our investigations revealed that low levels of taurine, a non-proteogenic sulfonic amino acid, were present within OC ascites. Taurine supplementation, beyond levels found in ascites, induced growth suppression without causing cytotoxicity in multiple OC cell cultures, including patient-derived chemotherapy-resistant spheroid and organoid cultures. Suppression of proliferation by taurine was associated with the inhibition of glycolysis, mitochondrial function, and the activation of p21 and TIGAR, theTP53-dependent and independent tumor suppression regulatory pathways. Expression of p21 or TIGAR in various OC cells, in part, mimicked taurine-induced inhibition of OC cell proliferation. Our data support the potential therapeutic value of taurine supplementation in OC after chemotherapy.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Farsinejad, S
(author)
-
Kochetkova, EKarolinska Institutet
(author)
-
Volpari, T
(author)
-
Gladych-Macioszek, A
(author)
-
Klupczynska-Gabryszak, A
(author)
-
Polotaye, T
(author)
-
Greenberg, M
(author)
-
Kung, D
(author)
-
Hyde, E
(author)
-
Alshehri, S
(author)
-
Pavlovic, T
(author)
-
Sullivan, W
(author)
-
Plewa, S
(author)
-
Vakifahmetoglu-Norberg, H
(author)
-
Monsma, FJ
(author)
-
Muller, PAJ
(author)
-
Matysiak, J
(author)
-
Zaborowski, M
(author)
-
DiFeo, A
(author)
-
Norberg, E
(author)
-
Martin, LA
(author)
-
Iwanicki, M
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:bioRxiv : the preprint server for biology: Cold Spring Harbor Laboratory
Internet link
Find in a library
To the university's database
- By the author/editor
-
Centeno, D
-
Farsinejad, S
-
Kochetkova, E
-
Volpari, T
-
Gladych-Maciosze ...
-
Klupczynska-Gabr ...
-
show more...
-
Polotaye, T
-
Greenberg, M
-
Kung, D
-
Hyde, E
-
Alshehri, S
-
Pavlovic, T
-
Sullivan, W
-
Plewa, S
-
Vakifahmetoglu-N ...
-
Monsma, FJ
-
Muller, PAJ
-
Matysiak, J
-
Zaborowski, M
-
DiFeo, A
-
Norberg, E
-
Martin, LA
-
Iwanicki, M
-
show less...
- Articles in the publication
- bioRxiv : the pr ...
- By the university
-
Karolinska Institutet