Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

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Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.

By the author/editor: Dec, E; Clement, J; Cheng, K; Church, GM; Fossel, MB; Rehkopf, DH; show more...; Rosero-Bixby, L; Kobor, MS; Lin, DT; Lu, AT; Fei, Z; Guo, W; Chew, YC; Yang, X; Putra, SED; Reiner, AP; Correa, A; Vilalta, A; Pirazzini, C; Passarino, G; Monti, D; Arosio, B; Garagnani, P; Franceschi, C; Horvath, S; show less...

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