Search: onr:"swepub:oai:research.chalmers.se:004d517b-5e31-4f75-bc18-831bc02c56b0" >
Immunoglobulin G N-...
-
Birukov, AnnaHarvard School of Public Health, United States
(author)
Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-10-25
-
American Diabetes Association,2022
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:research.chalmers.se:004d517b-5e31-4f75-bc18-831bc02c56b0
-
https://research.chalmers.se/publication/533138URI
-
https://doi.org/10.2337/dc22-0833DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatog-raphy, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC-Potsdam and independent validation studies (843 total cases, 3,149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37–1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG-GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Plavćsa, Branimir
(author)
-
Eichelmann, Fabian
(author)
-
Kuxhaus, Olga
(author)
-
Hoshi, Rosangela AkemiHarvard Medical School
(author)
-
Rudman, Najda
(author)
-
Stambuk, Tamara
(author)
-
Trbojevićc-Akmaćcićc, Irena
(author)
-
Schiborn, Catarina
(author)
-
Morze, JakubHarvard School of Public Health, United States,University of Warmia and Mazury in Olsztyn
(author)
-
Mihelćcićc, Matea
(author)
-
Cindrićc, Ana
(author)
-
Liu, YanyanHarvard Medical School
(author)
-
Demler, OlgaHarvard Medical School,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
(author)
-
Perola, MarkusHelsingin Yliopisto,University of Helsinki
(author)
-
Mora, SamiaHarvard Medical School
(author)
-
Schulze, Matthias B.Universität Potsdam,University of Potsdam
(author)
-
Lauc, Gordan
(author)
-
Wittenbecher, Clemens,1981Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)clemensw
(author)
-
Harvard School of Public Health, United StatesHarvard Medical School
(creator_code:org_t)
Related titles
-
In:Diabetes Care: American Diabetes Association45:11, s. 2729-27361935-55480149-5992
Internet link
Find in a library
To the university's database
- By the author/editor
-
Birukov, Anna
-
Plavćsa, Branimi ...
-
Eichelmann, Fabi ...
-
Kuxhaus, Olga
-
Hoshi, Rosangela ...
-
Rudman, Najda
-
show more...
-
Stambuk, Tamara
-
Trbojevićc-Akmać ...
-
Schiborn, Catari ...
-
Morze, Jakub
-
Mihelćcićc, Mate ...
-
Cindrićc, Ana
-
Liu, Yanyan
-
Demler, Olga
-
Perola, Markus
-
Mora, Samia
-
Schulze, Matthia ...
-
Lauc, Gordan
-
Wittenbecher, Cl ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and General Practice
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Diabetes Care
- By the university
-
Chalmers University of Technology