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Fluorinated beta-sh...
Fluorinated beta-sheet breaker peptides
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- Loureiro, J. A. (author)
- Universidade do Porto,University of Porto
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- Crespo, R. (author)
- Universidade do Porto,University of Porto
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- Borner, H. (author)
- Humboldt-Universität zu Berlin,Humboldt University of Berlin
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- Martins, P. M. (author)
- Universidade do Porto,University of Porto
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- Rocha, F. A. (author)
- Universidade do Porto,University of Porto
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- Coelho, M. A. N. (author)
- Universidade do Porto,University of Porto
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- Pereira, M. C. (author)
- Universidade do Porto,University of Porto
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- Rocha, Sandra, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2014-03-14
- 2014
- English.
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In: Journal of Materials Chemistry B. - : Royal Society of Chemistry (RSC). - 2050-7518 .- 2050-750X. ; 2:16, s. 2259-2264
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Abstract
Subject headings
Close
- The aggregation of amyloid-beta peptide (Ab) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease. We synthesized peptides containing fluorinated amino acids and studied their effect on the Ab aggregation. The peptides were based on the sequence LVFFD, in which valine was substituted by either 4,4,4-trifluorovaline or 4-fluoroproline, or the phenylalanine at position 3 was replaced by 3,4,5-trifluorophenylalanine. Our results demonstrate that fluorination of the hydrophobic residue valine or phenylalanine is effective in preventing the Ab aggregation. This study opens up the possibility of using new sequences based on fluorinated amino acids to inhibit the amyloid- fibril formation.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- 1978
- ANNUAL REVIEW OF BIOCHEMISTRY
- P251
- NANOPARTICLES
- OU PY
- V47
- ALZHEIMERS-DISEASE
- PATHOGENESIS
- AMYLOIDOGENICITY
- SOLID-STATE NMR
- PROTEIN
- CONFORMATION
- AMYLOID FIBRILS
- FIBRILLOGENESIS
- OLIGOMERS
Publication and Content Type
- art (subject category)
- ref (subject category)
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