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Prospects for syste...
Prospects for systems biology and modeling of the gut microbiome
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- Karlsson, Fredrik, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Petranovic Nielsen, Dina, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 29:6, s. 251-258
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Abstract
Subject headings
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- Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Keyword
- metabolic
- butyrate
- bacterial mutualism
- receptor
- diet-induced obesity
- chain fatty-acids
- human colonic microbiota
- protein-coupled
- reconstruction
- networks
- high-throughput
- inflammatory bowel diseases
Publication and Content Type
- art (subject category)
- ref (subject category)
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