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Prospects for syste...
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Karlsson, Fredrik,1984Chalmers tekniska högskola,Chalmers University of Technology
(author)
Prospects for systems biology and modeling of the gut microbiome
- Article/chapterEnglish2011
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LIBRIS-ID:oai:research.chalmers.se:06232537-4946-45fd-91ce-eb45ddc961ad
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https://research.chalmers.se/publication/142665URI
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https://doi.org/10.1016/j.tibtech.2011.01.009DOI
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Language:English
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Summary in:English
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Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.
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Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat
(author)
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Petranovic Nielsen, Dina,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)dinap
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Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
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Chalmers tekniska högskola
(creator_code:org_t)
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In:Trends in Biotechnology: Elsevier BV29:6, s. 251-2580167-77991879-3096
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