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“Notame”: Workflow ...
“Notame”: Workflow for non-targeted LC-MS metabolic profiling
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- Klåvus, Anton (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Kokla, Marietta (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Noerman, Stefania, 1987 (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Koistinen, Ville Mikael (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Tuomainen, Marjo (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Zarei, Iman (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Meuronen, Topi (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Häkkinen, Merja R. (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Rummukainen, Soile (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Babu, Ambrin Farizah (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Sallinen, Taisa (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Kärkkäinen, Olli (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Paananen, Jussi (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Broadhurst, David (author)
- Edith Cowan University
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- Brunius, Carl, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hanhineva, Kati, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland
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(creator_code:org_t)
- 2020-03-31
- 2020
- English.
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In: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 10:4
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Abstract
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- Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics in order to provide coherent and high-quality data that enable discovery of robust and biologically significant metabolic findings. In this protocol article, we introduce notame, an analytical workflow for non-targeted metabolic profiling approaches, utilizing liquid chromatography-mass spectrometry analysis. We provide an overview of lab protocols and statistical methods that we commonly practice for the analysis of nutritional metabolomics data. The paper is divided into three main sections: the first and second sections introducing the background and the study designs available for metabolomics research and the third section describing in detail the steps of the main methods and protocols used to produce, preprocess and statistically analyze metabolomics data and, finally, to identify and interpret the compounds that have emerged as interesting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Metabolomics
- Computational statistical
- Supervised learning
- Unsupervised learning
- Metabolic profiling
- LC-MS
- Pathway analysis
- Mass spectrometry
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Klåvus, Anton
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Kokla, Marietta
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Noerman, Stefani ...
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Koistinen, Ville ...
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Tuomainen, Marjo
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Zarei, Iman
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show more...
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Meuronen, Topi
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Häkkinen, Merja ...
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Rummukainen, Soi ...
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Babu, Ambrin Far ...
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Sallinen, Taisa
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Kärkkäinen, Olli
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Paananen, Jussi
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Broadhurst, Davi ...
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Brunius, Carl, 1 ...
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Hanhineva, Kati, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Metabolites
- By the university
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Chalmers University of Technology