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  • Messner, Christoph B.The Francis Crick Institute (author)

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:0a46d92f-75ee-4c7b-8ae1-121d81068133
  • https://research.chalmers.se/publication/517959URI
  • https://doi.org/10.1016/j.cels.2020.05.012DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They include complement factors, the coagulation system, inflammation modulators, and pro-inflammatory factors upstream and downstream of interleukin 6. All protocols and software for implementing our approach are freely available. In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Demichev, VadimThe Francis Crick Institute,University Of Cambridge (author)
  • Wendisch, DanielCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Michalick, LauraCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • White, MatthewThe Francis Crick Institute (author)
  • Freiwald, AnjaCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Textoris-Taube, KathrinCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Vernardis, Spyros I.The Francis Crick Institute (author)
  • Egger, Anna SophiaThe Francis Crick Institute (author)
  • Kreidl, MarcoThe Francis Crick Institute (author)
  • Ludwig, DanielaCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Kilian, ChristianeCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Agostini, FedericaCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Zelezniak, Aleksej,1984The Francis Crick Institute,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)alezel (author)
  • Thibeault, CharlotteCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Pfeiffer, MoritzCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Hippenstiel, StefanCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Hocke, AndreasCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • von Kalle, ChristofCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Campbell, ArchieUniversity of Edinburgh (author)
  • Hayward, CarolineUniversity of Edinburgh (author)
  • Porteous, David J.University of Edinburgh (author)
  • Marioni, Riccardo E.University of Edinburgh (author)
  • Langenberg, C.University Of Cambridge,The Francis Crick Institute (author)
  • Lilley, Kathryn S.University Of Cambridge (author)
  • Kuebler, Wolfgang M.Charité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Mülleder, MichaelCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Drosten, C.Charité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Suttorp, NorbertCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Witzenrath, MartinCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Kurth, FlorianCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Sander, Leif ErikCharité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Ralser, M.The Francis Crick Institute,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • The Francis Crick InstituteUniversity Of Cambridge (creator_code:org_t)

Related titles

  • In:Cell Systems: Elsevier BV11:1, s. 11-24.E42405-47122405-4720

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