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Search: onr:"swepub:oai:research.chalmers.se:11025c0f-79e3-45e2-a487-39a9a03f8342" > A systems biology a...

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  • Meijnikman, A. S.Universiteit Van Amsterdam,University of Amsterdam,Spaarne Gasthuis,Spaarne Hospital (author)

A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:11025c0f-79e3-45e2-a487-39a9a03f8342
  • https://doi.org/10.1016/j.isci.2022.104828DOI
  • https://research.chalmers.se/publication/531682URI
  • https://gup.ub.gu.se/publication/323379URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lappa, Dimitra,1988Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lappa (author)
  • Herrema, H.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Aydin, O.Spaarne Gasthuis,Spaarne Hospital,Universiteit Van Amsterdam,University of Amsterdam (author)
  • Krautkramer, Kimberly A.Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xkraki (author)
  • Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xtreva (author)
  • Olofsson, Louise,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xolofl (author)
  • Lundqvist, Annika (author)
  • Bruin, S. C.Spaarne Gasthuis,Spaarne Hospital (author)
  • Acherman, Y. I.Z.Spaarne Gasthuis,Spaarne Hospital (author)
  • Verheij, J.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Hjorth, S.Köpenhamns universitet,University of Copenhagen (author)
  • Gerdes, V. E.A.Spaarne Gasthuis,Spaarne Hospital,Universiteit Van Amsterdam,University of Amsterdam (author)
  • Schwartz, Thue W.Köpenhamns universitet,University of Copenhagen (author)
  • Groen, A. K.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xbafre (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Nieuwdorp, M.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Universiteit Van AmsterdamSpaarne Gasthuis (creator_code:org_t)

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  • In:iScience: Elsevier BV25:82589-0042

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