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A Systematic Review...
A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids
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- Di Pede, Giuseppe (författare)
- Universita degli Studi di Parma,University of Parma
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- Mena, Pedro (författare)
- Universita degli Studi di Parma,University of Parma
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- Bresciani, Letizia (författare)
- Universita degli Studi di Parma,University of Parma
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- Achour, Mariem (författare)
- Université Clermont Auvergne,Clermont Auvergne University
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- Lamuela-Raventós, Rosa M. (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII),Universitat de Barcelona,University of Barcelona
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- Estruch, Ramon (författare)
- Universitat de Barcelona,University of Barcelona,Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII)
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kulling, Sabine E. (författare)
- Max Rubner-Institut, Germany
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- Wishart, David (författare)
- University of Alberta
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- Rodriguez-Mateos, Ana (författare)
- King's College London
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- Clifford, Michael N. (författare)
- University of Surrey,Monash University
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- Crozier, Alan (författare)
- King Saud University,University of Glasgow
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- Manach, Claudine (författare)
- Université Clermont Auvergne,Clermont Auvergne University
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- Del Rio, Daniele (författare)
- Universita degli Studi di Parma,University of Parma
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Antioxidants and Redox Signaling. - 1523-0864 .- 1557-7716. ; 40:7-9, s. 510-541
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Significance: Hydroxycinnamic acids (HCAs) are the main phenolic acids in the western diet. Harmonizing the available information on the absorption, distribution, metabolism, and excretion (ADME) of HCAs is fundamental to unraveling the compounds responsible for their health effects. This work systematically assessed pharmacokinetics, including urinary recovery, and bioavailability of HCAs and their metabolites, based on literature reports.Recent Advances: Forty-seven intervention studies with coffee, berries, herbs, cereals, tomato, orange, grape products, and pure compounds, as well as other sources yielding HCA metabolites, were included. Up to 105 HCA metabolites were collected, mainly acyl-quinic and C-6-C-3 cinnamic acids. C-6-C-3 cinnamic acids, such as caffeic and ferulic acid, reached the highest blood concentrations (maximum plasma concentration [C-max] = 423 nM), with time to reach C-max (T-max) values ranging from 2.7 to 4.2 h. These compounds were excreted in urine in higher amounts than their phenylpropanoic acid derivatives (4% and 1% of intake, respectively), but both in a lower percentage than hydroxybenzene catabolites (11%). Data accounted for 16 and 18 main urinary and blood HCA metabolites, which were moderately bioavailable in humans (collectively 25%).Critical Issues: A relevant variability emerged. It was not possible to unequivocally assess the bioavailability of HCAs from each ingested source, and data from some plant based-foods were absent or inconsistent.Future Directions: A comprehensive study investigating the ADME of HCAs derived from their most important dietary sources is urgently required. Eight key metabolites were identified and reached interesting plasma C-max concentrations and urinary recoveries, opening up new perspectives to evaluate their bioactivity at physiological concentrations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- pharmacokinetics
- phenolics
- caffeoylquinic acids
- stoichiometry
- chlorogenic acids
- (poly)phenols
- metabolites
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- Av författaren/redakt...
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Di Pede, Giusepp ...
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Mena, Pedro
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Bresciani, Letiz ...
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Achour, Mariem
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Lamuela-Raventós ...
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Estruch, Ramon
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visa fler...
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Landberg, Rikard ...
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Kulling, Sabine ...
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Wishart, David
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Rodriguez-Mateos ...
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Clifford, Michae ...
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Crozier, Alan
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Manach, Claudine
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Del Rio, Daniele
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visa färre...
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