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Hepatitis C treatme...
Hepatitis C treatment response kinetics and impact of baseline predictors.
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Arnholm, B (author)
- Södra Älvsborgs Sjukhus (SÄS),Södra Älvsborg Hospital (SÄS)
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- Eilard, Anders (author)
- NU-sjukvården,NU Hospital Group
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- Färkkilä, Martti (author)
- Helsingin Yliopisto,University of Helsinki
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Langeland, Nina (author)
- Helse Bergen Haukeland University Hospital
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- Mørch, K (author)
- Helse Bergen Haukeland University Hospital
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics
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- Pedersen, Court (author)
- Syddansk Universitet,University of Southern Denmark
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- Buhl, Mads Rauning (author)
- Århus Universitet,Aarhus University
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- Wahlberg, T (author)
- Skaraborgs Sjukhus,Skaraborg Hospital
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- Wejstål, Rune, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Norkrans, Gunnar, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2011-04-24
- 2011
- English.
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In: Journal of Viral Hepatitis. - : Wiley. - 1365-2893 .- 1352-0504. ; 18:6, s. 400-407
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Summary. The optimal duration of treatment for hepatitis C virus (HCV) infections is highly variable but critical for achieving cure (sustained virological response, SVR). We prospectively investigated the impact of age, fibrosis, baseline viraemia and genotype on the early viral kinetics and treatment outcome. Patients treated with peginterferon alfa-2a and ribavirin in standard dosing were included: 49 with genotype 1 treated for 48 weeks and 139 with genotype 2 or 3 treated for 24 weeks. The reduced SVR rates in patients older than 45 years, with severe liver fibrosis or pretreatment viraemia above 400 000 IU/mL were strongly associated with slower second phase declines of HCV RNA. Genotype 2/3 infections responded more rapidly than genotype 1, reaching week 4 negativity (RVR) in 59%vs 22%. We conclude that baseline response predictors such as age, fibrosis and viral load were well reflected by the early viral kinetics as assessed by repeated HCV RNA quantifications. The kinetic patterns and the high relapse rate in genotype 2/3 patients without RVR suggest that this group might benefit from treatment durations longer than 24 weeks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- ribavirin
- genotype
- hepatitis
- pegylated interferon
- monitoring
- HCV RNA
- genotype; HCV RNA; hepatitis; monitoring; pegylated interferon; ribavirin
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lindh, Magnus, 1 ...
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Arnholm, B
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Eilard, Anders
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Färkkilä, Martti
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Hellstrand, Kris ...
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Lagging, Martin, ...
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show more...
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Langeland, Nina
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Mørch, K
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Nilsson, Staffan ...
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Pedersen, Court
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Buhl, Mads Rauni ...
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Wahlberg, T
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Wejstål, Rune, 1 ...
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Westin, Johan, 1 ...
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Norkrans, Gunnar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Journal of Viral ...
- By the university
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Chalmers University of Technology
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University of Gothenburg